Simulation of a HIV-1 virus infection of a CD4+T lymphocyte by Monte Carlo
Miguel Ramos Pascual
Scientific Essay from the year 2019 in the subject Biology - Virology, grade: -, , language: English, abstract: The Human Inmunodeficiency Virus (HIV) is a retrovirus which preferentially infects CD4+T lymphocytes of the human immune system during its replication cycle. Although the cycle is similar to other retroviruses, there are still aspects which remain unknown, so further research is still needed. Computerised biology brings the possibility to reproduce with low resources the virus replication cycle, focusing on those steps in which real laboratory conditions are difficult to achieve. The software HIV.pro has been developed to simulate by Monte Carlo methods the replication cycle of HIV-1 virus, providing estimators of HIV protein concentrations in the nucleous and cytoplasm, spliced and unspliced mrna concentrations, viral burst size, time and number of transcriptions for first virus release. HIV-1.pro software simulates acuratelly the intracelullar process of virus infection, providing reliable results of virus infectivity.
