<p>This book describes the physicochemical fundamentals and biomedical principles of drug solubility. Methods to study and predict solubility <em>in silico</em> and <em>in vitro</em> are described and the role of solubility in a medicinal chemistry and pharmaceutical industry context are discussed. Approaches to modify and control solubility of a drug during the manufacturing process and of the pharmaceutical product are essential practical aspects of this book. </p>