Untertitel:: Springer Theses
Verlag:: Springer Berlin
Erschienen:: 10.01.2012
Seitenanzahl:: 130
ISBN:: 364224632X
EAN:: 9783642246326
Format:: eBook
Schutz:: Dig. Wass.
Downloadzeit:: Maximaler Downloadzeitraum: 24 Monate

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Heteroaromatic Lipoxin A4 Analogues

Colm Duffy

<p>In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation. </p>